Rett syndrome, a rare genetic neurodevelopmental disorder, has a progressive disease course, making early identification and diagnosis imperative for optimal patient outcomes. Although no cure currently exists, there are several options available for supportive care and symptom management, and other interventions—both pharmacologic and nonpharmacologic—are in development. In this series of podcasts and ClinicalThoughts, experts in Rett syndrome shed light on the disease course and the current and emerging management options.