OPTIC: A Phase II Dose-Optimization Trial Evaluating 3 Different Starting Doses of Ponatinib in CP-CML

Source: 2021 ASCO Virtual Annual Meeting*
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June 4-8, 2021; Online at https://conferences.asco.org/am
Results from this study suggest that the benefit–risk profile of ponatinib is optimized by starting at a dose of 45 mg/day and reducing the dose to 15 mg/day upon achieving response (≤1% BCR-ABL1IS).
Format: Microsoft PowerPoint (.ppt)
File Size: 461 KB
Released: June 8, 2021

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Novartis Pharmaceuticals Corporation
Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc.
Sanofi Genzyme

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