Selecting First-line ART in Treatment-Naive Persons With HIV

In this episode, Princy N. Kumar, MD, FIDSA, MACP, discusses key considerations for selecting ART in treatment-naive persons with HIV. Her discussion includes:

• DHHS Treatment Guideline recommendations
• Choosing among first-line recommended integrase inhibitors
• Recommended regimens for rapid ART start
• Select key studies in treatment-naïve adults:
  • AMBER study of virologic response with DRV/COBI/FTC/TAF vs DRV/COBI + TFC/TDF
  • DRIVE-AHEAD and DRIVE-FORWARD efficacy study results, including resistance analyses of DOR + 2 NRTIs vs EFV or (DRV + RTV) + 2 NRTIs
  • Safety and efficacy results from GEMINI-1 and GEMINI comparing DTG + 3TC vs DTG + FTC/TDF
• The current/possible role of boosted PIs and NNRTIs
• Selection considerations between TDF and TAF