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Clinical Thought 1

Clinical Thought 2

Clinical Thought 3

Upon successful completion of the activities, participants should be better able to:

• Examine the metabolic adaptations that contribute to weight loss challenges in patients with obesity
• Describe the physiologic and metabolic effects of incretin-based therapies that lead to weight loss in patients with obesity and the benefits of sustained weight loss on obesity- related comorbidities
• Summarize the long-term efficacy and safety data of current and emerging incretin-based therapies for the treatment of patients with obesity

The Endocrine Society is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Endocrine Society has achieved Accreditation with Commendation.

AMA PRA Category 1 Credit
The Endocrine Society designates each activity in this course for a maximum of 1.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. While offering CME credits noted above, this program is not intended to provide extensive training or certification in the field.

Please note that while other accrediting bodies accept AMA PRA Category 1 credit, we can only award and report this credit for MDs/DOs. For those outside of this accreditation, please complete the participation evaluation and use that certificate as proof of attendance to submit to your accrediting body.

Maintenance of Certification (MOC) - if eligible
Successful completion of each CME activity in this course, which includes participation in the evaluation component, enables the participant to earn up to 1.50 points in the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For questions about content or obtaining CME credit, please contact the Endocrine Society at info@endocrine.org

Joint Accreditation Statement
In support of improving patient care, this activity has been planned and implemented by The Endocrine Society and Clinical Care Options, LLC (CCO). Clinical Care Options, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Nursing Continuing Education Credit Designation
The maximum number of hours awarded for this Continuing Nursing Education activity is 1.5 contact hours. For questions about obtaining Nursing credit, please contact Sophia Kelley at skelley@clinicaloptions.com.

Continuing Pharmacy Education Credit Designation
CCO designates this continuing education activity for 1.5 contact hours (0.15 CEUs) of the Accreditation Council for Pharmacy Education. Universal Activity Number - JA4008176-9999-21-018-L01-P.

Type of Activity: Knowledge

Upon successfully completing the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.

Disclosure of Conflicts of Interest 
Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any relevant conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

For questions about obtaining Pharmacy credit, please contact Sophia Kelley at skelley@clinicaloptions.com.

Kristina M. Utzschneider, MD
Associate Professor of Medicine
University of Washington
Seattle, WA

Randy J. Seeley, PhD
Professor of Surgery
University of Michigan
Ann Arbor, MI

Jenny Tong, MD, MPH
Associate Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
University of Washington
Seattle, WA

STATEMENT OF INDEPENDENCE
As a provider of CME accredited by the Accreditation Council for Continuing Medical Education, the Endocrine Society has a policy of ensuring that the content and quality of this educational activity are balanced, independent, objective, and scientifically rigorous. The scientific content of this activity was developed under the supervision of the Endocrine Society’s guideline task force.

DISCLOSURE POLICY
The faculty, committee members, and staff who are in position to control the content of this activity are required to disclose to the Endocrine Society and to learners any relevant financial relationship(s) of the individual or spouse/partner that have occurred within the last 12 months with any commercial interest(s) whose products or services are related to the content. Financial relationships are defined by remuneration in any amount from the commercial interest(s) in the form of grants; research support; consulting fees; salary; ownership interest (e.g., stocks, stock options, or ownership interest excluding diversified mutual funds); honoraria or other payments for participation in speakers' bureaus, advisory boards, or boards of directors; or other financial benefits. The intent of this disclosure is not to prevent planners with relevant financial relationships from planning or delivery of content, but rather to provide learners with information that allows them to make their own judgments of whether these financial relationships may have influenced the educational activity with regard to exposition or conclusion.

The following faculty reported relevant financial relationships:
Randy J. Seeley, PhD: Consulting Fee, Novo Nordisk, Sanofi-Aventis, Kintai, Scohia, Eli Lilly & Company, Ionis Pharmaceuticals Inc.; Grant Recipient, AstraZeneca, Novo Nordisk, Pfizer Global R&D, Kintai, Energesis; Stock Owner, Zafgen, Calibrate Health, Rewind Health.

The following faculty reported no relevant financial relationships: 
Kristina M. Utzschneider, MD, Jenny Tong, MD, MPH

The following SPC member who planned and reviewed content for this activity reported the following financial relationships: Amy E. Rothberg, MD, PhD: Spouse, Consultant of Merck

The following SPC Committee members reported financial relationships:

• Andjela T. Drincic, MD: Advisory Board Member, Corcept
• Sergio Fazio, MD, PhD: Consultant, Amarin, Amgen, Akcea, Aegerion, Esperion, Novartis
• Angela M. Leung, MD: Speaker, Medical Education Resources, MCE Conferences, ATA Board Member
• Katherine Araque, MD: Speaker, Novo Nordisk; Advisory Board, Corcept

The Endocrine Society has reviewed these relationships to determine which are relevant to the content of this activity and resolved any identified conflicts of interest for these individuals.

Disclosure information for presenters is included in their individual recorded presentations.

The following SPC members reported no relevant financial relationships:

Lorena Alarcon-Casas Wright, MD; Beret Casey, MD; Neena Natt, MD; Kelly Lauter Roszko, MD, PhD; Deborah Sellmeyer, MD; Savitha Subramanian, MD; Soleymani Taraneh, MD; Steven Weitzman, MD

The staff involved in the development of this CME activity reported no relevant financial relationships.

The Endocrine Society staff have reviewed all disclosures and resolved or managed all relevant identified conflicts of interest, as applicable.

ACKNOWLEDGMENT OF COMMERCIAL SUPPORT
This educational activity is supported by an independent medical educational grant from Novo Nordisk, Inc.